Immunotherapy

Dendritic Cell Therapy

Personalized immunotherapies based on dendritic cells — CytoCare provides the starting material for innovative treatment approaches.

Dendritic cells in immunotherapy
The Foundation

What are dendritic cells?

Dendritic cells are the most important antigen-presenting cells of the immune system. They serve as the bridge between innate and adaptive immunity.

In immunotherapy, monocytes are obtained from the blood and differentiated ex vivo into dendritic cells. These are loaded with tumor-specific antigens and returned to the patient to trigger a targeted immune response against cancer cells. This approach is being researched and increasingly used clinically for various solid tumors and hematological diseases.

CytoCare monocyte collection
Our Role

How CytoCare provides the starting material

The quality of dendritic cell therapy depends critically on the quality of the monocytes. CytoCare supplies leukapheresis products with high monocyte content as the optimal starting basis.

  • Leukapheresis with targeted enrichment of monocytes
  • High cell viability through gentle collection procedures
  • Fresh or cryopreserved delivery as required
  • GMP-compliant processes for clinical programs
  • Close coordination with the treating center
Request a consultation
The Process

From Leukapheresis to Immunotherapy

Leukapheresis
Gentle collection of mononuclear cells with a focus on high monocyte content.
Monocyte Isolation
Purification of monocytes from the leukapheresis product via elutriation or adherence.
DC Differentiation
Ex vivo differentiation of monocytes into immature dendritic cells over 5–7 days.
Antigen Loading
Loading of DCs with tumor-specific antigens and maturation into immunostimulatory cells.
Vaccination
Administration of the loaded dendritic cells to the patient to activate an immune response.
Fields of Application

Applications of dendritic cell therapy

Solid Tumors
DC vaccines are used for various solid tumors such as melanoma, prostate cancer, and renal cell carcinoma.
Glioblastoma
Promising clinical studies demonstrate the benefit of dendritic cell vaccines for brain tumors.
Combination Therapy
DC vaccines are increasingly being researched in combination with checkpoint inhibitors and other immunotherapies.
Clinical Trials
CytoCare supports academic and industrial research partners in conducting clinical DC studies.

Planning a DC therapy project?

Talk to our experts about optimal leukapheresis products for your dendritic cell therapy.

Request Information